Held by
1
portfolio on TandT
Bookmarked by
0
users
Avg position size
8.4%
of holders' portfolios
13F filers
0
institutions
Market cap
$115.6M
3M shares
52-week range
$7.26 – $240.00
15% from low
Sector
PHARMACEUTICAL PREPARATIONS
Exchange
NASDAQ
CS
Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.
www.sprucebiosciences.com| Trader / Portfolio | Conviction |
|---|---|
| July PortfolioShkreli | Mild8% |
No tracked institution reports a position in SPRB as of their last filing.
| Execution date | Ratio |
|---|---|
| 2025-08-07 | 1-for-75reverse |
$SPRB if there was options on this trash Id write some 25P for a few months out. This will be sub 35 by the time they get across the finish line as it slowly bleeds out. They diluted way too much and still might again but its still worth a stab after I sold at 52.
View on StockTwits ↗$SPRB Podcast last month with SPRB CEO..https://empoweredpatientradio.com/enzyme-replacement-therapy-for-sanfilippo-syndrome-type-b-with-dr-javier-szwarcberg-spruce-biosciences?fbclid=IwY2xjawTFKm1leHRuA2FlbQIxMABicmlkETFIa3RySlBXakE3OThyVmgzc3J0YwZhcHBfaWQQMjIyMDM5MTc4ODIwMDg5MgABHqES1j6K0OVzaXUnZu0XD5itBoD8HXSCGbjY47ONwf9QAhwQKy8HkVKBoUY__aem_gjQjSyYUMNw5-fO7_CWp5g
View on StockTwits ↗$SPRB still in the accumulation phase. The price is ugly the ultimate bottom is at 30s… good luck, usually price trend up proceeding the BLA, still 4 months and Half waiting time
View on StockTwits ↗$SPRB ask at 52 and the bid is at 46. This is a hedge fund walking down price with there short position.
View on StockTwits ↗B Riley🏁 $SPRB and said -- We are launching coverage on Spruce Biosciences (SPRB) with a Buy rating and a $160 PT. Here's what else B Riley had to say in its initiation report: https://x.com/Quantumup1/status/2076645837942186090?s=20
View on StockTwits ↗$SPRB the most worthless stock of all time ..Nothing can make this bitch go up
View on StockTwits ↗$UNCY Top priority! Russell 2026 Biotech Watchlist: , $GALT, $SPRB, $OVID and the Small-Cap Health Care Additions to Watch https://www.merlintrader.com/russell-2026-biotech-watchlist/
View on StockTwits ↗$ADTX I sat on bags $SPRB for years and they were delisted to OTC in 2025 and I sold at over $360. Anything can happen.
View on StockTwits ↗@JFais take a look at $SPRB just bought in around $47 and $RCKT has been up nicely as Danon similar to Qure relies on outside database. Sprb filing bla in q4
View on StockTwits ↗$SPRB Is there talks of a buyout? or is the main catalyst to watch out for in Q4 2026?
View on StockTwits ↗$SPRB Really crazy at this level. My only concern is potential competition from JCR down the road, but even they are several years behind.
View on StockTwits ↗Recent $TICKER stream from stocktwits.com — refreshed every 5 minutes. Sentiment tags are self-reported by posters. Not investment advice.
| Year | Est. revenue | Growth | Est. EPS | EPS range | Fwd P/E | # Analysts |
|---|---|---|---|---|---|---|
| 2026 | $54M | +2587.6% | $-24.58 | $-25.36–$-23.18 | — | 5 |
| 2027 | $87M | +61.4% | $3.10 | $-32.18–$28.17 | 13.5× | 5 |
| 2028 | $49M | -43.9% | $-8.07 | $-20.51–$7.84 | — | 4 |
| 2029 | $87M | +78.0% | $-2.13 | $-5.86–$0.32 | — | 2 |
Forward consensus · growth is YoY vs the prior fiscal-year estimate · Fwd P/E at the current price · source: Financial Modeling Prep
Beat consensus in 6 of the last 8 reported quarters
| Reported | Est. EPS | Actual | Surprise |
|---|---|---|---|
| 2026-05-13 | $-7.32 | $-8.94 | -22.1% |
| 2026-03-09 | $-12.87 | $-9.58 | +25.6% |
| 2025-11-10 | $-15.56 | $-14.58 | +6.3% |
| 2025-08-14 | $-18.05 | $-3.50 | +80.6% |
| 2025-05-06 | $-18.80 | $-24.06 | -28.0% |
| 2025-04-02 | $-0.24 | $-0.23 | +4.2% |
| 2024-11-11 | $-20.30 | $-15.79 | +22.2% |
| 2024-08-12 | $-24.81 |
| $-16.54 |
| +33.3% |
| $22M |
| — |
| IOBTIO Biotech, Inc. | $0.01 | -27.59% | $885690 | — |
| NRXPNRx Pharmaceuticals, Inc. | $3.63 | -3.20% | $63M | — |
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Ranked by collective conviction (sum of co-holders' % allocation) across public portfolios holding SPRB.
Click to see transaction details on SEC.gov. Form 4s cover trades by officers, directors, and 10%+ owners, due within 2 business days of the trade.